Chlorpromazine-Procyclidine Combination, Imipramine and Placebo in Depressive Disorders

Imipramine treatment of opiate-dependent patients with depressive disorders. A placebo-controlled trial.

BACKGROUND The literature is inconclusive on the role of antidepressant medications in treating drug dependence. Studies have either not focused on depressed patients or have selected patients with depressive disorders based on cross-sectional symptoms rather than a syndromal diagnosis. A clinical trial of an antidepressant was, therefore, conducted on drug-dependent patients with syndromal dep...

David Healy nervous conditions before and after chlorpromazine and imipramine

Imipramine in Schizophrenia with Depressive Symptomatology1

Depressive mood is a common accompaniment of schizophrenia. The present study was taken up with the aim to study the effect of imipramine on depressivse symptoms of schizophrenia. Eighteen patients of schizophrenia with depressive symptoms were studied under a double blind controlled design with a chlorpromazine-imipramine and a chlorpromazine-placebo group. Both the groups showed significant i...

Ect-chlorpromazine Combination Compared with Chlorpromazine Only in Schizophrenia1

Forty-four hospitalized schizophrenic patients, 22 in each of two groups, were treated for a period of 6 weeks with either EGT-GPZ combination or CPZ alone. Ratings on RP scale (Rockland and Pollin, 1S65) showed that the KGT-receiving group was significantly better en several measure at second week and also had an earlier onset of beneficial response on "Affect and Mood." However, at the end of...

Imipramine and "drinamyl" in Depressive Illness: a Comparative Trial.

were introduced five or six years ago. Proprietary mixtures of dexamphetamine and amylobarbitone are still advertised as of value in depression, and the lack of any comparative trial is perhaps more surprising when it is remembered that the basic cost to the National Health Service of a week's treatment with the ingredients of such mixtures (dexamphetamine sulphate 5 mg. and amylobarbitone sodi...